It's obvious that the Wolves are a looming threat to Alexandria, and how Rick responds to them is a major plot worth exploring in season 6.
It seems likely that the situation will devolve into warfare at first, but this AMC series has always done a stellar job of dealing with situations at a simmer when it needs to.
The real question becomes how Rick handles himself after the conflict. Will he unite with the remaining opposition members and allow them to stay in Alexandria? Will he chop off their heads in the town square?
Grimes has a history of using both tactics, so there's no telling which path he might take. This question ties into the violence versus sanity angle. Maybe the Wolves quarrel will be a deciding factor in the larger option that he chooses.